Just updated from dpupos 40 to 43. The installation is on a USB flash drive. Following the update I deleted the save folder to start fresh. I reload the firefox config from a backup.
Some minor issues:
After the initial setup and several reboots, the Pupmode is 66, so can't alter setting from Event Manager and unable to alter save. The extlinux.conf is as per release. I have also tried adding pfix=ram(not sure of syntax) to the Append line, but it has no effect, still remains as Pupmode 66.
On shutdown after seeing the dpupos is shutting down, I am always then dropped to tty1 command prompt and then have to do hard shutdown. In earlier version this was intermittent, now occurs all the time.
I also notice that the installation USB drive only displays a 'mounted' indicator in the top right corner, not the 'Home' indicator. When I click this drive, it runs pmount instead of opening the drive in rox.
Edit: On booting the 'home' indicator is displayed, after clicking this drive icon the indicator changes to the 'mounted' indicator.
Edit 2: So after needing to hard shutdown yesterday on all shutdowns/reboots, today I have shutdown and rebooted twice each without issue. So seems reporting the issue was enough to fix it.

Edit 3: OK I've done some checking and see that dpupos is structured differently than other pups. The /initrd directory itself appears to be the mount point of the drive partition that contains dpupos. There is no /initrd/mnt/dev_save (/mnt/home). When I look at the /mnt/sdb1 in rox even though it has the home indicator, it shows as unmounted when accessed by rox prior to mounting. So it is only accessible as /mnt/sdb1 after being clicked or a mount command issued. The drive icon still remains to appear mounted following clicking the mounted indicator, or issuing a umount command. This probably should revert to the home indicator.